Search for associations between polymorphic variants of human acid chitinase gene and bronchial asthma in children of Novosibirsk

High prevalence of bronchial asthma among the population (about 300 million people all over world) provides rationale for search candidate genes disease. Human acidic chitinase (CHIA (AMCase)), encoded by CHIA gene, is involved in degradation chitin, a component fungal cell wall and arthropod exoskeleton, which, if present food or house dust, provoking factor (BA) development. Functionally significant mutations gene may apparently increase risk susceptibility to BA. Aim. The aim study was assess associations single nucleotide polymorphisms (SNPs) rs12033184 rs3806448 with children Novosibirsk. Material Methods . organized as case-control. A total 537 blood samples were used. SNPs determined real-time PCR. polymorphic variants disease assessed odds ratio. Results. No BA found. Conclusion. role development residents Novosibirsk found be less than Indian where it previously shown associated